Molecular glues are small molecules that can modify protein structure to alter function. The Tumor Necrosis Factor superfamily (TNFSF) is a group of signaling proteins involved in regulating immune responses and mediating inflammation and autoimmune diseases. 

We are advancing the rational design and development of molecular glues called “superglues” that target TNFSF ligands to deliver biologic-like efficacy in inflammatory and autoimmune diseases.